Secreted klotho

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August undefined, 2024

WebKlotho is an anti-aging factor mainly produced by renal tubular epithelial cells (TEC) with pleiotropic functions. Klotho is down-regulated in acute kidney injury in native kidney; however, the modulation of Klotho in kidney transplantation has not been investigated. In a swine model of ischemia/reperfusion injury (IRI), we observed a remarkable reduction of … WebChillon M. AAV-mediated expression of secreted and transmembrane aKlotho isoforms rescue relevant aging hallmarks in senescent SAMP8 mice. Aging Cell ... Bosch A, Giménez-Llort L, Chillon M. Secreted-Klotho isoform administered into CNS protects against age-dependent memory deficits in middle-aged and aged animals. Molecular Psychiatry (2024 ...

Identification of the human klotho gene and its two

WebSecreted Klotho functions as a humoral factor that regulates activity of multiple glycoproteins on the cell surface, including ion channels and growth factor receptors such … Web12 Mar 2024 · Senescent cells cause reduced α-Klotho, partially due to their production of activin A and IL-1α. Targeting senescent cells boosts α-Klotho in mice and humans. Thus, clearing senescent cells restores α-Klotho, potentially opening a novel, translationally-feasible avenue for developing orally-active small molecule, α-Klotho-enhancing clinical … dr michael herndon alexandria alabama

A novel antibody for the detection of alternatively spliced secreted ...

WebSecreted Klotho functions as a humoral factor with pleiotropic activities, including suppression of growth factor signaling, suppression of oxidative stress, and regulation of … WebAcromegaly is characterized by excessively high GH and IGF1 levels. Recent data suggest that soluble Klotho (sKlotho) is also elevated in patients with active acromegaly. sKlotho decreases towards normal following removal of the GH-producing pituitary adenoma. The Klotho gene was identified in mice following its accidental disruption by ectopic DNA. It is … Webtor 19 (FGF-19), a hormone produced in enterocytes that regulates hepatic bile acid (BA) synthesis. Other potential causes include genetic variations that affect the proteins ... cytes or genetic variations of FGFR4 or b-klotho lead to excess bile acid concentration in the colon, resulting in activation of the G protein-coupled bile acid ... dr. michael hermann chattanooga t

Klotho and SIRT1 Expression in Renal Aging Related Disease IJGM

Secreted Klotho protein in sera and CSF: implication for post ...

Web31 Oct 2024 · These changes were specific to the secreted Klotho isoform since expression of the m-KL transmembrane isoform was not affected either by s-KL overexpression … Web19 Nov 2024 · The Klotho proteins, αKlotho and βKlotho, are essential components of endocrine fibroblast growth factor (FGF) receptor complexes, as they are required for the … dr michael herman urologistWeb2 Apr 2024 · The klotho gene family consists of α-, β-, and γ-Klotho, which encode type I single-pass transmembrane proteins with large extracellular domains. α-Klotho exists as … dr michael herbowy rochester

"WebTaken together, these results suggest that secreted Klotho inhibits EGF-induced pro-migratory cell morphological changes and migration in Caki-1 cells. Our data additionally suggest that decreased ... " - Secreted klotho

Secreted klotho

Rubén Cereijo Téllez - Postdoctoral Research Fellow (Juan de la …

Web19 Jan 2024 · Membrane-bound Klotho is a 130 kDa single-pass transmembrane protein that is encoded by a KL gene. The extracellular domain of the Klotho protein can be cleaved and separated from the cell membrane by the metalloproteinases ADAM-10 and ADAM-17 (ADAM—a disintegrin and metalloproteinase domain-containing protein) and β-secretase … Web4 Apr 2024 · The data suggest that secreted Klotho protein attenuates the osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro through FGFR1/ERK signaling. Data revealed the existence of a moderating effect between Klotho and STC1, where Klotho may inhibit thyroid tumor progression by inhibiting the tumor marker level of …

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Web20 Jun 2024 · The α-Klotho predominantly exists in two forms as follows: a single-pass transmembrane protein and a soluble protein that circulates in the blood, urine, and cerebrospinal fluid . Although the α-Klotho is mainly expressed in kidneys, its expression in both human and mouse arteries has also been demonstrated (9, 10). Web22 Oct 2024 · The klotho family and structure. Klotho family members include α-, β-, and γ-klotho genes based on their predicted primary sequences [18, 19]. β- and γ-klotho were discovered based on their homology with α-klotho, and they all share a single-pass transmembrane protein [20, 21]. β-Klotho is predominantly expressed in the liver but is …

WebThe levels of β-klotho (KLB), the co-receptor required for FGF21 action, are decreased in brown (BAT) and white (WAT) adipose tissues during obesity, diabetes, and lipodystrophy. ... whereas BAT-secreted myostatin and 12,13-diHOME influence skeletal muscle development and performance. Further research is needed to ascertain in humans the role ... WebKlotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain. The extracellular domain of Klotho, a type-1 membrane protein, is secre

Web5 Jul 2011 · As klotho is an endogenous hormone, its administration is potentially feasible and may serve as a novel therapy for pancreatic, as well as other cancers. As diagnosis of pancreatic cancer is often cytology-based, the identification of reliable histological markers is of utmost importance. WebEmerging evidence reveals that Klotho deficiency is an early biomarker for chronic kidney diseases as well as a pathogenic factor. Klotho deficiency is associated with progression …

WebSecreted Klotho is detected in the blood, urine, and cerebrospinal fluid. Klotho is expressed in multiple tissues and cell types and at particularly high levels in the kidney. Klotho is abundantly expressed in the distal … dr michael hernandez pulmonologist npiWeb7 May 2004 · Surprisingly the secreted Klotho was 130 kDa, in contrast to the 70 kDa predicted form from klotho gene transcripts. The secreted as well as the membrane … dr michael herman urologyWeb30 Apr 2024 · We have been conducting ongoing investigations to identify a novel therapeutic factor against kidney disease. We focused on Klotho, an anti-aging protein … dr michael herockWeb27 Nov 2007 · The fact that Klotho is secreted suggested that enzymes that act like scissors must be involved in the liberation of Klotho from the cell membrane. Dr. Ci-Di Chen, an assistant professor working ... dr michael herrick molineWebKlotho protects CHs viability by suppressing oxidative stress and inflammation, which is associated with the mediation of FOXO1 and FOXO3. Purpose: To investigate the effect of Klotho and FOXO1/3 on the CH viability in OA.Methods: The survival rate of CHs, Klotho and FOXO1/3 protein expression, and ROS production were measured in the OA cartilages of … dr. michael hernandez fort lee njWeb3 May 2006 · These researchers speculated that the paracrine action of secreted Klotho through its association with FGF receptors on nearby cells might cause these phenotypes. Klotho might be required for the recognition of FGF23 by a target cell. If this is the case, the FGF23 signal could probably be transduced into the distal convoluted tubule cells ... cold war armored vehiclesWebThe klotho gene expresses a secreted form, lacking KL2, transmembrane, and intracellular domains, due to alternative RNA splicing. These plasmids were created by your colleagues. Please acknowledge the Principal Investigator, cite the article in which the plasmids were described, and include Addgene in the Materials and Methods of your future ... cold war armageddon tv