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Webb23 juli 2024 · PROTACs are molecules which cause protein degradation. Protein degradation is akin to gene knockout: it can provide insight into the cellular functions of proteins. Simultaneous binding of a target protein and an E3 ligase by a PROTAC within a key ternary complex facilitates ubiquitylation of the target protein. Webb22 sep. 2024 · Here we describe the development of proteolysis-targeting antibodies (PROTABs) that tether cell-surface E3 ubiquitin ligases to transmembrane proteins, resulting in target degradation both in vitro and in vivo. mercedesbenz workers on vacation brazil chips
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