Dynein intermediate chain 2 ciliary

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August undefined, 2024

WebPrimary ciliary dyskinesia. More than 80 mutations in the DNAH5 gene have been found to cause primary ciliary dyskinesia, which is a condition characterized by respiratory tract infections, abnormal organ placement, and an inability to have children (infertility).DNAH5 gene mutations result in an absent or abnormal heavy chain 5. Without a normal version … WebJul 8, 2009 · The human dynein intermediate chain 2 gene (DNAI2): cloning, mapping, expression pattern, and evaluation as a candidate for primary ciliary dyskinesia. Source: Springer Science and Business Media LLC To beat or not to beat: roles of cilia in development and disease

Dynein - Wikipedia

WebSep 30, 2024 · 37 of dynein motor proteins coordinate their activity to drive ciliary bending wave propagation. Dynein-38 associated light and intermediate chains regulate the biophysical mechanisms of axonemal dynein. Tctex-39 type outer arm dynein light chain 2 (LC2) regulates flagellar bending wave propagation direction, WebLOC105686446 dynein intermediate chain 2, ciliary [ (coleseed sawfly)] Gene ID: 105686446, updated on 21-Jan-2024. Summary Other designations. dynein … daughter of flowers

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WebDec 28, 2010 · Many individuals with PCD have a mutation in a gene encoding a component of the outer dynein arms (molecular motors that power the 9+2 ciliary cytoskeleton or axoneme), particularly in one of the ... Web1 day ago · Outer dynein arms in the ciliary axoneme generate force for ciliary beating. Here, cryo-electron tomography study of the outer dynein arm from the unicellular alga C. reinhardtii revealed structures of multiple intermediate and prepower stroke states in the presence of ATP, as well as structural differences between in situ and in vitro … WebMost of these cases result from mutation in genes encoding dynein-2 components, such as the heavy chain DYNC2H1 gene (Baujat et al., 2013) and the intermediate chain DYNC212 gene (previously known ... bk precision 9205 user manual

Light chain 2 is a Tctex-type related axonemal dynein light …

WebJun 28, 2024 · The dynein-2 complex mediates trafficking of ciliary proteins by powering the intraflagellar transport (IFT) machinery containing IFT-A and IFT-B complexes. Although 11 subunits are known to constitute the … WebOct 15, 2024 · Dynein-2 is responsible for retrograde transport in cilia and flagella. Primary (non-motile) cilia are hair-like extensions present on … bkprecision 9801WebDec 8, 2024 · Located in 9+2 motile cilium; axoneme; and external side of plasma membrane. Is expressed in spermatozoon and testis. Used to study Kartagener syndrome and primary ciliary dyskinesia. Human ortholog (s) of this gene implicated in primary ciliary dyskinesia 9. Orthologous to human DNAI2 (dynein axonemal intermediate chain 2). … bk precision 9151

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Dynein intermediate chain 2 ciliary

1767 - Gene ResultDNAH5 dynein axonemal heavy chain 5

WebNov 17, 2008 · Specific Antibodies Localize the Human Axonemal Outer Dynein Arm Intermediate Chain 2 (DNAI2) to the Respiratory Ciliary Axoneme and Sperm Tail (A) Western blot analysis of protein extracts from human nasal cell culture (M, protein standard; lane 1, silver staining). DNAI2 antibodies specifically detect a single band with the … WebDec 16, 2013 · Dynein intermediate chain 2 (DNAI2) may be a candidate gene for PCD/KS according to a report by Pennarun et al.50 It comprises 14 exons, ... Liu Y, et al. CCDC103 mutations cause primary ciliary dyskinesia by disrupting assembly of ciliary dynein arms. Nat Genet. 2012; 44:714–9. [PMC free article] [Google Scholar]

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WebSep 26, 2024 · Dynein-associated light and intermediate chains regulate the biophysical mechanisms of axonemal dynein. Tctex-type outer arm dynein light chain 2 ... In summary, we identified TbLC2 as a ciliary … WebDynein Axonemal Light Chain 4 (DNAL4) protein is understood to be part of the axonemal (or ciliary and flagellar) complex of dynein molecules (including dynein heavy and light chains) (GO:0005858) and a component of the microtubule-based dynein motor complex [13].In humans, two known axonemal light chain proteins, DNAL1 and DNAL4, sit at the …

WebEnter the email address you signed up with and we'll email you a reset link. WebJul 1, 2024 · The Wdr34 gene encodes an intermediate chain of cytoplasmic dynein 2, the motor for retrograde intraflagellar transport (IFT) in primary cilia. ... Consistent with its …

Web1 day ago · Outer dynein arms in the ciliary axoneme generate force for ciliary beating. Here, cryo-electron tomography study of the outer dynein arm from the unicellular alga … WebMar 1, 2024 · The dynein-2 complex drives retrograde ciliary protein trafficking by associating with the intraflagellar transport (IFT) machinery, containing IFT-A and IFT-B complexes. ... that incorporation of DYNLL1/DYNLL2 and DYNLRB1/DYNLRB2 into the dynein-2 complex via interactions with the WDR34 intermediate chain is crucial for …

WebAug 8, 2024 · There is compelling evidence that, in contrast with the dynein-1 intermediate chain, WDR34 does not homodimerize: the endogenous protein fails to co-immunoprecipitate with GFP ... At the ciliary tip, the dynein-2 motor domains must be activated via disruption of the auto-inhibitory interface, releasing the linker and stalk …

Each molecule of the dynein motor is a complex protein assembly composed of many smaller polypeptide subunits. Cytoplasmic and axonemal dynein contain some of the same components, but they also contain some unique subunits. Cytoplasmic dynein, which has a molecular mass of about 1.5 megadaltons (MDa), is a dimer of dimers, containing approximately twelve polypeptide sub… daughter of fluttercordWebNov 1, 2024 · Dynein axonemal intermediate chain 2 (Dnaic2) is a homologue of human DNAI2, which is associated with PCD. 21 Dnaic2 is highly expressed in oocytes and sperms. Dnaic2 ‐overexpressed mice show lung damage, male sterility, and female subfertility or infertility. In the Dnaic2 ‐overexpressed mouse, there are structural abnormalities of the ... bk precision ba6011WebMay 1, 2001 · The dynein heavy chain family of isoforms is divided into four functional classes: (i) axonemal (ciliary or flagellar) outer arm dyneins; (ii) axonemal inner arm dyneins; (iii) non-axonemal (‘cytoplasmic’) ... The orange box denotes a region crucial for dimerization of the heavy chain and binding of the intermediate chain. (b, c ... bk precision ba6010WebIn individual 2, one rare variant (c.9110A > G;p.(H3037R)) in the dynein axonemal heavy chain 11 gene (DNAH11), coding for another component of the outer dynein arm, was identified. Both DNAH5 and ADGRV1 contribute to ciliary function. A novel mutation causing primary ciliary dyskinesia was found in Japanese patients. bk precision benchtop power supplyWebSep 30, 2024 · Dynein- associated light and intermediate chains regulate the biophysical mechanisms of axonemal dynein. ... contribute to pathogenic kinetoplastids’ unique tip-to-base ciliary beating nature and how those mechanisms underlie dynein-driven ciliary motility more generally. ... Tctex- type outer arm dynein light chain 2 (LC2) regulates ... daughter off poles lyricsWebFeb 5, 2013 · 605483 - DYNEIN, AXONEMAL, INTERMEDIATE CHAIN 2; DNAI2 - DNAI2 In 3 patients with primary ciliary dyskinesia-9 (CILD9; 612444), Loges et al. (2008) … bk precision bk9115WebPrimary Ciliary Dyskinesia. Margaret W. Leigh MD, in Kendig & Chernick's Disorders of the Respiratory Tract in Children (Eighth Edition), 2012. Dynein arm defects. ... Indeed, a direct interaction has been shown between dynein intermediate chain and KLCs. The interaction of these proteins may reflect a requirement for kinesin to bring dynein to ... bk precision 9206b