Chemotherapy atra
WebSep 25, 2024 · OPTIMAL DOSE OF ATRA IN INDUCTION AND CONSOLIDATION. Studies that have investigated the treatment of APL … WebNov 9, 2001 · All trans retinoic acid (ATRA) is able to induce complete remission (CR) in almost all patients with acute promyelocytic leukemia (APL) through in vivo differentiation of APL blasts. However, it ...
Chemotherapy atra
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WebDec 10, 2009 · Investigators at the Shanghai Institute of Hematology combined ATRA, ATO, and chemotherapy in induction, administered intensive chemotherapy and consolidation, and gave maintenance and reported a CR rate of 93% and a disease-free survival of 94% with an overall survival of 98%. 61 Investigators at the M. D. Anderson Cancer Center … WebAug 15, 2024 · Acute promyelocytic leukemia (APL) has become a highly curable disease. 1-4 All-trans retinoic acid (ATRA) and arsenic trioxide (ATO) are the backbone of modern treatments for APL and have led to complete remission (CR) in 90% to 100% of patients in clinical trials and an overall survival (OS) between 86% and 97%. 5-15 The practice …
WebChemotherapy (an anthracycline) plus ATO; ATRA plus ATO is often the preferred treatment in people at lower risk of the leukemia coming back, as it tends to have fewer … WebUpdated results from the APL0406 study suggest that the combination of all-trans retinoic acid (ATRA) plus arsenic trioxide (ATO) was associated with greater long-term event-free survival (EFS) and disease-free survival (DFS) in patients with low- and intermediate-risk acute promyelocytic leukemia (APL), compared with ATRA plus chemotherapy (ATRA …
WebOct 18, 2024 · Acute promyelocytic leukemia (APL) has become curable over 95% patients under a complete chemo-free treatment with all-trans retinoic acid (ATRA) and arsenic trioxide in low-risk patients. Minimizing chemotherapy has proven feasible in high-risk patients. We evaluated oral arsenic and ATRA without chemotherapy as an outpatient … WebMay 5, 2024 · Chemotherapy combined with other treatments may be one of the ways to solve chemotherapy resistance of HCC. 15,17,18 All-trans retinoic acid (ATRA), a key metabolite of vitamin A, is regarded as the first effective targeted therapy for acute promyelocytic leukemia (APL), and its effects have rarely been reported in solid cancers. …
WebAug 3, 2024 · ATRA/ATO treatment resulted in a lower relapse rates and higher event free survival compared to the standard chemotherapy regimen, though no differences in …
hcm showerWebApr 1, 2024 · Fenaux P, Le Deley MC, Castaigne S, Archimbaud E, Chomienne C, Link H, Guerci A, Duarte M, Daniel MT, Bowen D, et al. Effect of all transretinoic acid in newly diagnosed acute promyelocytic leukemia. Results of a multicenter randomized trial. European APL 91 Group. Blood. 1993 Dec 1;82(11):3241-9. gold cricket batWebMay 1, 2014 · The randomized nature of this study, which compared conventional ATRA plus chemotherapy with ATRA plus ATO in newly diagnosed patients, 7 has permitted a comparison of the incidence and severity of DS in both types of therapies in patients with WBC counts of 10 × 10 9 /L or less. The incidence of DS was not statistically different in … hcms.kdn.com:7003WebThe long-term survival rate was lower in patients treated with chemotherapy alone. Chemotherapy combined with ATRA or ATO showed a significantly improved OS rate and recurrence-free survival rate compared with chemotherapy alone. The highest OS rate was achieved when ATRA, ATO, and chemotherapy are combined and used alternatively. hcm short forWebWith the introduction of all-trans retinoic acid (ATRA) and arsenic trioxide (ATO), substantial advances have been made in the treatment profile for acute promyelocytic leukemia (APL) in the last two decades. ... APL treatment has evolved from ATRA + chemotherapy as a standard regimen to a dual-induction regimen involving a … hcmshrWebJul 11, 2013 · Background: All-trans retinoic acid (ATRA) with chemotherapy is the standard of care for acute promyelocytic leukemia (APL), resulting in cure rates … hcm shotcreteWebFor longer-term maintenance, ATRA might be used by itself or with chemo. ATRA can have side effects similar to those seen if you take too much vitamin A. Symptoms … gold crimp tubes